dolichyl-phosphate mannosyltransferase polypeptide 3
Symbol
DPM3
(may also be known as: None)
Organism
Human
Description
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a subunit of dolichyl-phosphate mannosyltransferase and acts as a stabilizer subunit of the dolichyl-phosphate mannosyltransferase complex. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| CG33977-RA | Drosophila melanogaster | |
| dpm3 | Danio rerio | |
| Dpm3 | Mus musculus | |
| Dpm3 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0005975 | carbohydrate metabolic process | biological_process | |
| GO:0006488 | dolichol-linked oligosaccharide biosynthetic process | biological_process | |
| GO:0006501 | C-terminal protein lipidation | biological_process | |
| GO:0006506 | GPI anchor biosynthetic process | biological_process | |
| GO:0018279 | protein N-linked glycosylation via asparagine | biological_process | |
| GO:0018406 | protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan | biological_process | |
| GO:0031647 | regulation of protein stability | biological_process | |
| GO:0035268 | protein mannosylation | biological_process | |
| GO:0035269 | protein O-linked mannosylation | biological_process | |
| GO:0043687 | post-translational protein modification | biological_process | |
| GO:0044267 | cellular protein metabolic process | biological_process | |
| GO:0005783 | endoplasmic reticulum | cellular_component | |
| GO:0005789 | endoplasmic reticulum membrane | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0030176 | integral to endoplasmic reticulum membrane | cellular_component | |
| GO:0031501 | mannosyltransferase complex | cellular_component | |
| GO:0033185 | dolichol-phosphate-mannose synthase complex | cellular_component | |
| GO:0004582 | dolichyl-phosphate beta-D-mannosyltransferase activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |