podocalyxin-like

Symbol

PODXL (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
podxl Danio rerio
Podxl Mus musculus
Podxl Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2647 Hypermethylation of PODXL is positively correlated with age Molecular blood Human PODXL —

GO Terms

GO IDGO TermGO Category
GO:0007162 negative regulation of cell adhesion biological_process
GO:0016477 cell migration biological_process
GO:0022408 negative regulation of cell-cell adhesion biological_process
GO:0030335 positive regulation of cell migration biological_process
GO:0032534 regulation of microvillus assembly biological_process
GO:0033634 positive regulation of cell-cell adhesion mediated by integrin biological_process
GO:0050900 leukocyte migration biological_process
GO:0072015 glomerular visceral epithelial cell development biological_process
GO:0072175 epithelial tube formation biological_process
GO:0001726 ruffle cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005813 centrosome cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0015629 actin cytoskeleton cellular_component
GO:0016324 apical plasma membrane cellular_component
GO:0030027 lamellipodium cellular_component
GO:0030175 filopodium cellular_component
GO:0031528 microvillus membrane cellular_component
GO:0043231 intracellular membrane-bounded organelle cellular_component
GO:0045121 membrane raft cellular_component