sphingosine-1-phosphate receptor 5

Symbol

S1PR5 (may also be known as: None)

Organism

Human

Description

The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]

Orthologs

SymbolSpecies
S1pr5 Mus musculus
S1pr5 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3885 Gene expression of S1PR5 increases with age Molecular skin Human S1PR5 —

GO Terms

GO IDGO TermGO Category
GO:0005886 plasma membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0004871 signal transducer activity molecular_function
GO:0004872 receptor activity molecular_function
GO:0004930 G-protein coupled receptor activity molecular_function
GO:0038036 sphingosine-1-phosphate receptor activity molecular_function