serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

Symbol

SERPINE2 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Orthologs

SymbolSpecies
serpine2 Danio rerio
Serpine2 Mus musculus
Serpine2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3322 Gene expression of SERPINE2 decreases with age Molecular skin Human SERPINE2 —

GO Terms

GO IDGO TermGO Category
GO:0007275 multicellular organismal development biological_process
GO:0007399 nervous system development biological_process
GO:0007566 embryo implantation biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0009314 response to radiation biological_process
GO:0009611 response to wounding biological_process
GO:0010544 negative regulation of platelet activation biological_process
GO:0010757 negative regulation of plasminogen activation biological_process
GO:0010766 negative regulation of sodium ion transport biological_process
GO:0010951 negative regulation of endopeptidase activity biological_process
GO:0010955 negative regulation of protein processing biological_process
GO:0010976 positive regulation of neuron projection development biological_process
GO:0014067 negative regulation of phosphatidylinositol 3-kinase cascade biological_process
GO:0021683 cerebellar granular layer morphogenesis biological_process
GO:0030154 cell differentiation biological_process
GO:0030195 negative regulation of blood coagulation biological_process
GO:0030308 negative regulation of cell growth biological_process
GO:0030334 regulation of cell migration biological_process
GO:0032940 secretion by cell biological_process
GO:0033363 secretory granule organization biological_process
GO:0042177 negative regulation of protein catabolic process biological_process
GO:0042628 mating plug formation biological_process
GO:0045861 negative regulation of proteolysis biological_process
GO:0045879 negative regulation of smoothened signaling pathway biological_process
GO:0048505 regulation of timing of cell differentiation biological_process
GO:0048711 positive regulation of astrocyte differentiation biological_process
GO:0050974 detection of mechanical stimulus involved in sensory perception biological_process
GO:0051966 regulation of synaptic transmission, glutamatergic biological_process
GO:0060291 long-term synaptic potentiation biological_process
GO:0060384 innervation biological_process
GO:0061108 seminal vesicle epithelium development biological_process
GO:0061110 dense core granule biogenesis biological_process
GO:0090331 negative regulation of platelet aggregation biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0005624 membrane fraction cellular_component
GO:0005829 cytosol cellular_component
GO:0031012 extracellular matrix cellular_component
GO:0031091 platelet alpha granule cellular_component
GO:0031232 extrinsic to external side of plasma membrane cellular_component
GO:0031594 neuromuscular junction cellular_component
GO:0043025 neuronal cell body cellular_component
GO:0004867 serine-type endopeptidase inhibitor activity molecular_function
GO:0005102 receptor binding molecular_function
GO:0005515 protein binding molecular_function
GO:0005539 glycosaminoglycan binding molecular_function
GO:0008201 heparin binding molecular_function
GO:0030414 peptidase inhibitor activity molecular_function