serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Symbol
SERPINA1
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| Serpina1e | Mus musculus | |
| Serpina1 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0001666 | response to hypoxia | biological_process | |
| GO:0002576 | platelet degranulation | biological_process | |
| GO:0006953 | acute-phase response | biological_process | |
| GO:0006954 | inflammatory response | biological_process | |
| GO:0007596 | blood coagulation | biological_process | |
| GO:0010288 | response to lead ion | biological_process | |
| GO:0010951 | negative regulation of endopeptidase activity | biological_process | |
| GO:0014070 | response to organic cyclic compound | biological_process | |
| GO:0030162 | regulation of proteolysis | biological_process | |
| GO:0030168 | platelet activation | biological_process | |
| GO:0032355 | response to estradiol stimulus | biological_process | |
| GO:0032496 | response to lipopolysaccharide | biological_process | |
| GO:0033986 | response to methanol | biological_process | |
| GO:0034014 | response to triglyceride | biological_process | |
| GO:0034097 | response to cytokine stimulus | biological_process | |
| GO:0046687 | response to chromate | biological_process | |
| GO:0005576 | extracellular region | cellular_component | |
| GO:0005578 | proteinaceous extracellular matrix | cellular_component | |
| GO:0005615 | extracellular space | cellular_component | |
| GO:0031093 | platelet alpha granule lumen | cellular_component | |
| GO:0002020 | protease binding | molecular_function | |
| GO:0004867 | serine-type endopeptidase inhibitor activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |