glutaredoxin 5
Symbol
GLRX5
(may also be known as: None)
Organism
Human
Description
This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, May 2010]
Orthologs
| Symbol | Species | |
|---|---|---|
| glrx-5 | Caenorhabditis elegans | |
| CG14407 | Drosophila melanogaster | |
| glrx5 | Danio rerio | |
| Glrx5 | Mus musculus | |
| Glrx5 | Rattus norvegicus | |
| GRX5 | Saccharomyces cerevisiae | |
| grx5 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0030097 | hemopoiesis | biological_process | |
| GO:0045454 | cell redox homeostasis | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005739 | mitochondrion | cellular_component | |
| GO:0009055 | electron carrier activity | molecular_function | |
| GO:0015035 | protein disulfide oxidoreductase activity | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |
| GO:0051537 | 2 iron, 2 sulfur cluster binding | molecular_function | |