lymphoid enhancer-binding factor 1

Symbol

LEF1 (may also be known as: None)

Organism

Human

Description

This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Orthologs

SymbolSpecies
lef1 Danio rerio
Lef1 Mus musculus
Lef1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3844 Gene expression of LEF1 decreases with age Molecular skin Human LEF1 —

GO Terms

GO IDGO TermGO Category
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0001569 patterning of blood vessels biological_process
GO:0001649 osteoblast differentiation biological_process
GO:0001755 neural crest cell migration biological_process
GO:0001756 somitogenesis biological_process
GO:0001822 kidney development biological_process
GO:0001837 epithelial to mesenchymal transition biological_process
GO:0001944 vasculature development biological_process
GO:0002040 sprouting angiogenesis biological_process
GO:0006917 induction of apoptosis biological_process
GO:0007155 cell adhesion biological_process
GO:0007420 brain development biological_process
GO:0008284 positive regulation of cell proliferation biological_process
GO:0010226 response to lithium ion biological_process
GO:0010628 positive regulation of gene expression biological_process
GO:0010718 positive regulation of epithelial to mesenchymal transition biological_process
GO:0014070 response to organic cyclic compound biological_process
GO:0016055 Wnt receptor signaling pathway biological_process
GO:0016202 regulation of striated muscle tissue development biological_process
GO:0021542 dentate gyrus development biological_process
GO:0021854 hypothalamus development biological_process
GO:0021861 forebrain radial glial cell differentiation biological_process
GO:0021873 forebrain neuroblast division biological_process
GO:0021879 forebrain neuron differentiation biological_process
GO:0021943 formation of radial glial scaffolds biological_process
GO:0022008 neurogenesis biological_process
GO:0022407 regulation of cell-cell adhesion biological_process
GO:0022408 negative regulation of cell-cell adhesion biological_process
GO:0022409 positive regulation of cell-cell adhesion biological_process
GO:0030111 regulation of Wnt receptor signaling pathway biological_process
GO:0030223 neutrophil differentiation biological_process
GO:0030307 positive regulation of cell growth biological_process
GO:0030326 embryonic limb morphogenesis biological_process
GO:0030335 positive regulation of cell migration biological_process
GO:0030509 BMP signaling pathway biological_process
GO:0030854 positive regulation of granulocyte differentiation biological_process
GO:0030879 mammary gland development biological_process
GO:0031100 organ regeneration biological_process
GO:0032696 negative regulation of interleukin-13 production biological_process
GO:0032713 negative regulation of interleukin-4 production biological_process
GO:0032714 negative regulation of interleukin-5 production biological_process
GO:0033153 T cell receptor V(D)J recombination biological_process
GO:0042100 B cell proliferation biological_process
GO:0042475 odontogenesis of dentin-containing tooth biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process biological_process
GO:0043392 negative regulation of DNA binding biological_process
GO:0043586 tongue development biological_process
GO:0043588 skin development biological_process
GO:0043923 positive regulation by host of viral transcription biological_process
GO:0043966 histone H3 acetylation biological_process
GO:0043967 histone H4 acetylation biological_process
GO:0045063 T-helper 1 cell differentiation biological_process
GO:0045843 negative regulation of striated muscle tissue development biological_process
GO:0045892 negative regulation of transcription, DNA-dependent biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0046632 alpha-beta T cell differentiation biological_process
GO:0048069 eye pigmentation biological_process
GO:0048341 paraxial mesoderm formation biological_process
GO:0048468 cell development biological_process
GO:0048699 generation of neurons biological_process
GO:0048747 muscle fiber development biological_process
GO:0050909 sensory perception of taste biological_process
GO:0060021 palate development biological_process
GO:0060033 anatomical structure regression biological_process
GO:0060070 canonical Wnt receptor signaling pathway biological_process
GO:0060325 face morphogenesis biological_process
GO:0060326 cell chemotaxis biological_process
GO:0060561 apoptosis involved in morphogenesis biological_process
GO:0060710 chorio-allantoic fusion biological_process
GO:0061153 trachea gland development biological_process
GO:0071353 cellular response to interleukin-4 biological_process
GO:0071864 positive regulation of cell proliferation in bone marrow biological_process
GO:0071866 negative regulation of apoptosis in bone marrow biological_process
GO:0071895 odontoblast differentiation biological_process
GO:0071899 negative regulation of estrogen receptor binding biological_process
GO:0090068 positive regulation of cell cycle process biological_process
GO:0090090 negative regulation of canonical Wnt receptor signaling pathway biological_process
GO:0005634 nucleus cellular_component
GO:0005667 transcription factor complex cellular_component
GO:0005737 cytoplasm cellular_component
GO:0032993 protein-DNA complex cellular_component
GO:0003677 DNA binding molecular_function
GO:0003682 chromatin binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0003705 sequence-specific distal enhancer binding RNA polymerase II transcription factor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0008013 beta-catenin binding molecular_function
GO:0008134 transcription factor binding molecular_function
GO:0008301 DNA binding, bending molecular_function
GO:0030284 estrogen receptor activity molecular_function
GO:0030331 estrogen receptor binding molecular_function
GO:0035326 enhancer binding molecular_function
GO:0042393 histone binding molecular_function
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process molecular_function
GO:0043565 sequence-specific DNA binding molecular_function
GO:0044212 transcription regulatory region DNA binding molecular_function
GO:0045295 gamma-catenin binding molecular_function
GO:0070016 armadillo repeat domain binding molecular_function
GO:0070742 C2H2 zinc finger domain binding molecular_function