SH3-domain GRB2-like endophilin B1
Symbol
SH3GLB1
(may also be known as: None)
Organism
Human
Description
This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Orthologs
| Symbol | Species | |
|---|---|---|
| erp-1 | Caenorhabditis elegans | |
| endoB | Drosophila melanogaster | |
| sh3glb1 | Danio rerio | |
| Sh3glb1 | Mus musculus | |
| Sh3glb1 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006915 | apoptotic process | biological_process | |
| GO:0006916 | anti-apoptosis | biological_process | |
| GO:0007165 | signal transduction | biological_process | |
| GO:0032461 | positive regulation of protein oligomerization | biological_process | |
| GO:0046847 | filopodium assembly | biological_process | |
| GO:0051259 | protein oligomerization | biological_process | |
| GO:0000139 | Golgi membrane | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005739 | mitochondrion | cellular_component | |
| GO:0005741 | mitochondrial outer membrane | cellular_component | |
| GO:0005794 | Golgi apparatus | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0008093 | cytoskeletal adaptor activity | molecular_function | |
| GO:0008289 | lipid binding | molecular_function | |
| GO:0017124 | SH3 domain binding | molecular_function | |
| GO:0042803 | protein homodimerization activity | molecular_function | |