abhydrolase domain containing 5

Symbol

ABHD5 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. It differs from other members of this subfamily in that its putative catalytic triad contains an asparagine instead of the serine residue. Mutations in this gene have been associated with Chanarin-Dorfman syndrome, a triglyceride storage disease with impaired long-chain fatty acid oxidation. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
C37H5.2 Caenorhabditis elegans
CG1882 Drosophila melanogaster
abhd5a Danio rerio
Abhd5 Mus musculus
Abhd5 Rattus norvegicus
ECM18 Saccharomyces cerevisiae

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3836 Gene expression of ABHD5 decreases with age Molecular skin Human ABHD5 —

GO Terms

GO IDGO TermGO Category
GO:0006508 proteolysis biological_process
GO:0006629 lipid metabolic process biological_process
GO:0006631 fatty acid metabolic process biological_process
GO:0006654 phosphatidic acid biosynthetic process biological_process
GO:0008654 phospholipid biosynthetic process biological_process
GO:0010891 negative regulation of sequestering of triglyceride biological_process
GO:0010898 positive regulation of triglyceride catabolic process biological_process
GO:0019433 triglyceride catabolic process biological_process
GO:0030154 cell differentiation biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0051006 positive regulation of lipoprotein lipase activity biological_process
GO:0005737 cytoplasm cellular_component
GO:0005811 lipid particle cellular_component
GO:0005829 cytosol cellular_component
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity molecular_function
GO:0004177 aminopeptidase activity molecular_function
GO:0004806 triglyceride lipase activity molecular_function
GO:0016746 transferase activity, transferring acyl groups molecular_function
GO:0042171 lysophosphatidic acid acyltransferase activity molecular_function