Rho guanine nucleotide exchange factor (GEF) 4

Symbol

ARHGEF4 (may also be known as: None)

Organism

Human

Description

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The protein encoded by this gene may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jun 2013]

Orthologs

SymbolSpecies
Arhgef4 Mus musculus
Arhgef4 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3831 Gene expression of ARHGEF4 increases with age Molecular skin Human ARHGEF4 —

GO Terms

GO IDGO TermGO Category
GO:0006915 apoptotic process biological_process
GO:0007264 small GTPase mediated signal transduction biological_process
GO:0008624 induction of apoptosis by extracellular signals biological_process
GO:0030032 lamellipodium assembly biological_process
GO:0035023 regulation of Rho protein signal transduction biological_process
GO:0035556 intracellular signal transduction biological_process
GO:0046847 filopodium assembly biological_process
GO:0048011 nerve growth factor receptor signaling pathway biological_process
GO:0051056 regulation of small GTPase mediated signal transduction biological_process
GO:0005622 intracellular cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0005886 plasma membrane cellular_component
GO:0032587 ruffle membrane cellular_component
GO:0042995 cell projection cellular_component
GO:0005085 guanyl-nucleotide exchange factor activity molecular_function
GO:0005089 Rho guanyl-nucleotide exchange factor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0019904 protein domain specific binding molecular_function
GO:0030676 Rac guanyl-nucleotide exchange factor activity molecular_function