natriuretic peptide receptor 3

Symbol

NPR3 (may also be known as: None)

Organism

Human

Description

This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

Orthologs

SymbolSpecies
npr3 Danio rerio
Npr3 Mus musculus
Npr3 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2818 Gene expression of NPR3 increases with age Molecular adipose tissue Human NPR3 —

GO Terms

GO IDGO TermGO Category
GO:0001501 skeletal system development biological_process
GO:0002158 osteoclast proliferation biological_process
GO:0007193 inhibition of adenylate cyclase activity by G-protein signaling pathway biological_process
GO:0007200 activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger biological_process
GO:0008217 regulation of blood pressure biological_process
GO:0033688 regulation of osteoblast proliferation biological_process
GO:0035810 positive regulation of urine volume biological_process
GO:0005624 membrane fraction cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0004872 receptor activity molecular_function
GO:0016941 natriuretic peptide receptor activity molecular_function
GO:0017046 peptide hormone binding molecular_function
GO:0042562 hormone binding molecular_function
GO:0042803 protein homodimerization activity molecular_function