NIMA-related kinase 3
Symbol
NEK3
(may also be known as: None)
Organism
Human
Description
This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
Orthologs
| Symbol | Species | |
|---|---|---|
| nekl-2 | Caenorhabditis elegans | |
| zgc:113355 | Danio rerio | |
| Nek3 | Mus musculus | |
| Nek3 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | biological_process | |
| GO:0007049 | cell cycle | biological_process | |
| GO:0007067 | mitosis | biological_process | |
| GO:0051301 | cell division | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0030424 | axon | cellular_component | |
| GO:0042995 | cell projection | cellular_component | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0004672 | protein kinase activity | molecular_function | |
| GO:0004674 | protein serine/threonine kinase activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0005524 | ATP binding | molecular_function | |
| GO:0016772 | transferase activity, transferring phosphorus-containing groups | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |