antioxidant 1 copper chaperone
Symbol
ATOX1
(may also be known as: None)
Organism
Human
Description
This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| cuc-1 | Caenorhabditis elegans | |
| Atox1 | Drosophila melanogaster | |
| atox1 | Danio rerio | |
| Atox1 | Mus musculus | |
| Atox1 | Rattus norvegicus | |
| ATX1 | Saccharomyces cerevisiae | |
| atx1 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006811 | ion transport | biological_process | |
| GO:0006825 | copper ion transport | biological_process | |
| GO:0006878 | cellular copper ion homeostasis | biological_process | |
| GO:0006979 | response to oxidative stress | biological_process | |
| GO:0030001 | metal ion transport | biological_process | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0005507 | copper ion binding | molecular_function | |
| GO:0016530 | metallochaperone activity | molecular_function | |
| GO:0016531 | copper chaperone activity | molecular_function | |
| GO:0032767 | copper-dependent protein binding | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |