nucleosome assembly protein 1-like 4
Symbol
NAP1L4
(may also be known as: None)
Organism
Human
Description
This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| Nap1 | Drosophila melanogaster | |
| nap1l4b | Danio rerio | |
| Nap1l4 | Mus musculus | |
| Nap1l4 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category |
|---|---|---|
| GO:0006334 | nucleosome assembly | biological_process |
| GO:0005634 | nucleus | cellular_component |
| GO:0005678 | chromatin assembly complex | cellular_component |
| GO:0005737 | cytoplasm | cellular_component |
| GO:0051082 | unfolded protein binding | molecular_function |