mevalonate (diphospho) decarboxylase
Symbol
MVD
(may also be known as: None)
Organism
Human
Description
The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| CELE_Y48B6A.13 | Caenorhabditis elegans | |
| CG8239 | Drosophila melanogaster | |
| mvd | Danio rerio | |
| Mvd | Mus musculus | |
| Mvd | Rattus norvegicus | |
| MVD1 | Saccharomyces cerevisiae | |
| mvd1 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006695 | cholesterol biosynthetic process | biological_process | |
| GO:0008284 | positive regulation of cell proliferation | biological_process | |
| GO:0008299 | isoprenoid biosynthetic process | biological_process | |
| GO:0019287 | isopentenyl diphosphate biosynthetic process, mevalonate pathway | biological_process | |
| GO:0042493 | response to drug | biological_process | |
| GO:0044281 | small molecule metabolic process | biological_process | |
| GO:0005625 | soluble fraction | cellular_component | |
| GO:0005777 | peroxisome | cellular_component | |
| GO:0005782 | peroxisomal matrix | cellular_component | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0004163 | diphosphomevalonate decarboxylase activity | molecular_function | |
| GO:0005524 | ATP binding | molecular_function | |
| GO:0016301 | kinase activity | molecular_function | |
| GO:0016829 | lyase activity | molecular_function | |
| GO:0030544 | Hsp70 protein binding | molecular_function | |
| GO:0042803 | protein homodimerization activity | molecular_function | |