msh homeobox 1

Symbol

MSX1 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in this gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
vab-15 Caenorhabditis elegans
msxe Danio rerio
Msx1 Mus musculus
Msx1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3273 Gene expression of MSX1 decreases with age Molecular skin Human MSX1 —

GO Terms

GO IDGO TermGO Category
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0000902 cell morphogenesis biological_process
GO:0001701 in utero embryonic development biological_process
GO:0001837 epithelial to mesenchymal transition biological_process
GO:0003007 heart morphogenesis biological_process
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation biological_process
GO:0007275 multicellular organismal development biological_process
GO:0007517 muscle organ development biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0009952 anterior/posterior pattern specification biological_process
GO:0010463 mesenchymal cell proliferation biological_process
GO:0023019 signal transduction involved in regulation of gene expression biological_process
GO:0030262 apoptotic nuclear change biological_process
GO:0030308 negative regulation of cell growth biological_process
GO:0030513 positive regulation of BMP signaling pathway biological_process
GO:0030900 forebrain development biological_process
GO:0030901 midbrain development biological_process
GO:0034504 protein localization to nucleus biological_process
GO:0035115 embryonic forelimb morphogenesis biological_process
GO:0035116 embryonic hindlimb morphogenesis biological_process
GO:0035880 embryonic nail plate morphogenesis biological_process
GO:0042474 middle ear morphogenesis biological_process
GO:0042475 odontogenesis of dentin-containing tooth biological_process
GO:0042481 regulation of odontogenesis biological_process
GO:0043065 positive regulation of apoptotic process biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0048863 stem cell differentiation biological_process
GO:0050821 protein stabilization biological_process
GO:0051154 negative regulation of striated muscle cell differentiation biological_process
GO:0060021 palate development biological_process
GO:0060325 face morphogenesis biological_process
GO:0060349 bone morphogenesis biological_process
GO:0060536 cartilage morphogenesis biological_process
GO:0061180 mammary gland epithelium development biological_process
GO:0061312 BMP signaling pathway involved in heart development biological_process
GO:2000678 negative regulation of transcription regulatory region DNA binding biological_process
GO:0005634 nucleus cellular_component
GO:0005667 transcription factor complex cellular_component
GO:0000982 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity molecular_function
GO:0002039 p53 binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0043565 sequence-specific DNA binding molecular_function