macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
Symbol
MST1R
(may also be known as: None)
Organism
Human
Description
This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternatively spliced transcript variants encoding different isoforms with different structural and biochemical properties have been described (PMID:8816464). [provided by RefSeq, Oct 2011]
Orthologs
| Symbol | Species | |
|---|---|---|
| mst1ra | Danio rerio | |
| Mst1r | Mus musculus | |
| Mst1r | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006928 | cellular component movement | biological_process | |
| GO:0006952 | defense response | biological_process | |
| GO:0007165 | signal transduction | biological_process | |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | biological_process | |
| GO:0007275 | multicellular organismal development | biological_process | |
| GO:0007338 | single fertilization | biological_process | |
| GO:0008284 | positive regulation of cell proliferation | biological_process | |
| GO:0009615 | response to virus | biological_process | |
| GO:0045087 | innate immune response | biological_process | |
| GO:0001725 | stress fiber | cellular_component | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0005887 | integral to plasma membrane | cellular_component | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0004872 | receptor activity | molecular_function | |
| GO:0005011 | macrophage colony-stimulating factor receptor activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0005524 | ATP binding | molecular_function | |