aspartoacylase
Symbol
ASPA
(may also be known as: None)
Organism
Human
Description
This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| aspa | Danio rerio | |
| Aspa | Mus musculus | |
| Aspa | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006533 | aspartate catabolic process | biological_process | |
| GO:0008152 | metabolic process | biological_process | |
| GO:0022010 | central nervous system myelination | biological_process | |
| GO:0048714 | positive regulation of oligodendrocyte differentiation | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0004046 | aminoacylase activity | molecular_function | |
| GO:0016788 | hydrolase activity, acting on ester bonds | molecular_function | |
| GO:0019807 | aspartoacylase activity | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |