molybdenum cofactor synthesis 1
Symbol
Organism
Description
Molybdenum cofactor biosynthesis is a conserved pathway leading to the biological activation of molybdenum. The protein encoded by this gene is involved in this pathway. This gene was originally thought to produce a bicistronic mRNA with the potential to produce two proteins (MOCS1A and MOCS1B) from adjacent open reading frames. However, only the first open reading frame (MOCS1A) has been found to encode a protein from the putative bicistronic mRNA, whereas additional splice variants, whose full-length natures have yet to be determined, are likely to produce a fusion between the two open reading frames. This gene is defective in patients with molybdenum cofactor deficiency, type A. A related pseudogene has been identified on chromosome 16. [provided by RefSeq, Jan 2010]
Orthologs
| Symbol | Species | |
|---|---|---|
| CELE_F49H6.5 | Caenorhabditis elegans | |
| Mocs1 | Drosophila melanogaster | |
| mocs1 | Danio rerio | |
| Mocs1 | Mus musculus | |
| Mocs1 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006766 | vitamin metabolic process | biological_process | |
| GO:0006767 | water-soluble vitamin metabolic process | biological_process | |
| GO:0006777 | Mo-molybdopterin cofactor biosynthetic process | biological_process | |
| GO:0032324 | molybdopterin cofactor biosynthetic process | biological_process | |
| GO:0044281 | small molecule metabolic process | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0019008 | molybdopterin synthase complex | cellular_component | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0003824 | catalytic activity | molecular_function | |
| GO:0005525 | GTP binding | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |
| GO:0051539 | 4 iron, 4 sulfur cluster binding | molecular_function | |