MHC class I polypeptide-related sequence A

Symbol

MICA (may also be known as: None)

Organism

Human

Description

MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq]

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2165 MHC class I polypeptide-related sequence A increases with age Molecular frontal lobe Human MICA 39.5% Increase Gene Expression Level
DAA2348 MHC class I polypeptide-related sequence A increases with age Molecular frontal lobe Human MICA 37.9% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0002223 stimulatory C-type lectin receptor signaling pathway biological_process
GO:0002418 immune response to tumor cell biological_process
GO:0006955 immune response biological_process
GO:0006974 response to DNA damage stimulus biological_process
GO:0009408 response to heat biological_process
GO:0019835 cytolysis biological_process
GO:0019882 antigen processing and presentation biological_process
GO:0042742 defense response to bacterium biological_process
GO:0046629 gamma-delta T cell activation biological_process
GO:0050776 regulation of immune response biological_process
GO:0051607 defense response to virus biological_process
GO:0005615 extracellular space cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0009986 cell surface cellular_component
GO:0016020 membrane cellular_component
GO:0042612 MHC class I protein complex cellular_component
GO:0030881 beta-2-microglobulin binding molecular_function
GO:0046703 natural killer cell lectin-like receptor binding molecular_function