MHC class I polypeptide-related sequence A
Symbol
MICA
(may also be known as: None)
Organism
Human
Description
MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
Links to external resources
Changes associated with this gene
Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
---|---|---|---|---|---|---|---|
DAA2165 | MHC class I polypeptide-related sequence A increases with age | Molecular | frontal lobe | Human | MICA | 39.5% Increase Gene Expression Level | |
DAA2348 | MHC class I polypeptide-related sequence A increases with age | Molecular | frontal lobe | Human | MICA | 37.9% Increase Gene Expression Level |
GO Terms
GO ID | GO Term | GO Category | |
---|---|---|---|
GO:0002223 | stimulatory C-type lectin receptor signaling pathway | biological_process | |
GO:0002418 | immune response to tumor cell | biological_process | |
GO:0006955 | immune response | biological_process | |
GO:0006974 | response to DNA damage stimulus | biological_process | |
GO:0009408 | response to heat | biological_process | |
GO:0019835 | cytolysis | biological_process | |
GO:0019882 | antigen processing and presentation | biological_process | |
GO:0042742 | defense response to bacterium | biological_process | |
GO:0046629 | gamma-delta T cell activation | biological_process | |
GO:0050776 | regulation of immune response | biological_process | |
GO:0051607 | defense response to virus | biological_process | |
GO:0005615 | extracellular space | cellular_component | |
GO:0005737 | cytoplasm | cellular_component | |
GO:0005886 | plasma membrane | cellular_component | |
GO:0005887 | integral to plasma membrane | cellular_component | |
GO:0009986 | cell surface | cellular_component | |
GO:0016020 | membrane | cellular_component | |
GO:0042612 | MHC class I protein complex | cellular_component | |
GO:0030881 | beta-2-microglobulin binding | molecular_function | |
GO:0046703 | natural killer cell lectin-like receptor binding | molecular_function | |