mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase

Symbol

MGAT1 (may also be known as: None)

Organism

Human

Description

There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
gly-13 Caenorhabditis elegans
Mgat1 Drosophila melanogaster
mgat1a Danio rerio
Mgat1 Mus musculus
Mgat1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3266 Gene expression of MGAT1 decreases with age Molecular skin Human MGAT1 —

GO Terms

GO IDGO TermGO Category
GO:0005975 carbohydrate metabolic process biological_process
GO:0006486 protein glycosylation biological_process
GO:0006487 protein N-linked glycosylation biological_process
GO:0018279 protein N-linked glycosylation via asparagine biological_process
GO:0043687 post-translational protein modification biological_process
GO:0044267 cellular protein metabolic process biological_process
GO:0000139 Golgi membrane cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity molecular_function
GO:0008375 acetylglucosaminyltransferase activity molecular_function
GO:0016757 transferase activity, transferring glycosyl groups molecular_function
GO:0046872 metal ion binding molecular_function