myocyte enhancer factor 2A

Symbol

MEF2A (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]

Orthologs

SymbolSpecies
mef2aa Danio rerio
Mef2a Mus musculus
Mef2a Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3264 Gene expression of MEF2A increases with age Molecular skin Human MEF2A —

GO Terms

GO IDGO TermGO Category
GO:0000002 mitochondrial genome maintenance biological_process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0000165 MAPKKK cascade biological_process
GO:0002224 toll-like receptor signaling pathway biological_process
GO:0002755 MyD88-dependent toll-like receptor signaling pathway biological_process
GO:0002756 MyD88-independent toll-like receptor signaling pathway biological_process
GO:0006351 transcription, DNA-dependent biological_process
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0006366 transcription from RNA polymerase II promoter biological_process
GO:0006915 apoptotic process biological_process
GO:0007275 multicellular organismal development biological_process
GO:0007399 nervous system development biological_process
GO:0007507 heart development biological_process
GO:0007517 muscle organ development biological_process
GO:0008063 Toll signaling pathway biological_process
GO:0034130 toll-like receptor 1 signaling pathway biological_process
GO:0034134 toll-like receptor 2 signaling pathway biological_process
GO:0034138 toll-like receptor 3 signaling pathway biological_process
GO:0034142 toll-like receptor 4 signaling pathway biological_process
GO:0035666 TRIF-dependent toll-like receptor signaling pathway biological_process
GO:0042692 muscle cell differentiation biological_process
GO:0045087 innate immune response biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0048011 nerve growth factor receptor signaling pathway biological_process
GO:0048311 mitochondrion distribution biological_process
GO:0048813 dendrite morphogenesis biological_process
GO:0051149 positive regulation of muscle cell differentiation biological_process
GO:0051403 stress-activated MAPK cascade biological_process
GO:0055005 ventricular cardiac myofibril development biological_process
GO:0061337 cardiac conduction biological_process
GO:0070375 BMK cascade biological_process
GO:0071277 cellular response to calcium ion biological_process
GO:0000790 nuclear chromatin cellular_component
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding molecular_function
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity molecular_function
GO:0001085 RNA polymerase II transcription factor binding molecular_function
GO:0001105 RNA polymerase II transcription coactivator activity molecular_function
GO:0003677 DNA binding molecular_function
GO:0003682 chromatin binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0003705 sequence-specific distal enhancer binding RNA polymerase II transcription factor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0019901 protein kinase binding molecular_function
GO:0033613 activating transcription factor binding molecular_function
GO:0035035 histone acetyltransferase binding molecular_function
GO:0042826 histone deacetylase binding molecular_function
GO:0043565 sequence-specific DNA binding molecular_function
GO:0046332 SMAD binding molecular_function
GO:0046982 protein heterodimerization activity molecular_function
GO:0046983 protein dimerization activity molecular_function