SMAD family member 3

Symbol

SMAD3 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009]

Orthologs

SymbolSpecies
smad3a Danio rerio
Smad3 Mus musculus
Smad3 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3257 Gene expression of SMAD3 increases with age Molecular skin Human SMAD3 —

GO Terms

GO IDGO TermGO Category
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0001501 skeletal system development biological_process
GO:0001657 ureteric bud development biological_process
GO:0001666 response to hypoxia biological_process
GO:0001701 in utero embryonic development biological_process
GO:0001707 mesoderm formation biological_process
GO:0001756 somitogenesis biological_process
GO:0001836 release of cytochrome c from mitochondria biological_process
GO:0001889 liver development biological_process
GO:0001933 negative regulation of protein phosphorylation biological_process
GO:0001947 heart looping biological_process
GO:0002076 osteoblast development biological_process
GO:0002520 immune system development biological_process
GO:0006810 transport biological_process
GO:0006917 induction of apoptosis biological_process
GO:0006919 activation of caspase activity biological_process
GO:0006955 immune response biological_process
GO:0007050 cell cycle arrest biological_process
GO:0007179 transforming growth factor beta receptor signaling pathway biological_process
GO:0007183 SMAD protein complex assembly biological_process
GO:0007369 gastrulation biological_process
GO:0007492 endoderm development biological_process
GO:0008633 activation of pro-apoptotic gene products biological_process
GO:0009880 embryonic pattern specification biological_process
GO:0010694 positive regulation of alkaline phosphatase activity biological_process
GO:0010718 positive regulation of epithelial to mesenchymal transition biological_process
GO:0016202 regulation of striated muscle tissue development biological_process
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway biological_process
GO:0019049 evasion of host defenses by virus biological_process
GO:0030308 negative regulation of cell growth biological_process
GO:0030335 positive regulation of cell migration biological_process
GO:0030501 positive regulation of bone mineralization biological_process
GO:0030878 thyroid gland development biological_process
GO:0031053 primary miRNA processing biological_process
GO:0032332 positive regulation of chondrocyte differentiation biological_process
GO:0032731 positive regulation of interleukin-1 beta production biological_process
GO:0032909 regulation of transforming growth factor beta2 production biological_process
GO:0032916 positive regulation of transforming growth factor beta3 production biological_process
GO:0033689 negative regulation of osteoblast proliferation biological_process
GO:0035413 positive regulation of catenin import into nucleus biological_process
GO:0042060 wound healing biological_process
GO:0042110 T cell activation biological_process
GO:0042177 negative regulation of protein catabolic process biological_process
GO:0042993 positive regulation of transcription factor import into nucleus biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0045216 cell-cell junction organization biological_process
GO:0045668 negative regulation of osteoblast differentiation biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0045930 negative regulation of mitotic cell cycle biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0048340 paraxial mesoderm morphogenesis biological_process
GO:0048589 developmental growth biological_process
GO:0048617 embryonic foregut morphogenesis biological_process
GO:0048701 embryonic cranial skeleton morphogenesis biological_process
GO:0050678 regulation of epithelial cell proliferation biological_process
GO:0050728 negative regulation of inflammatory response biological_process
GO:0050776 regulation of immune response biological_process
GO:0050821 protein stabilization biological_process
GO:0050927 positive regulation of positive chemotaxis biological_process
GO:0051098 regulation of binding biological_process
GO:0051496 positive regulation of stress fiber assembly biological_process
GO:0051894 positive regulation of focal adhesion assembly biological_process
GO:0060039 pericardium development biological_process
GO:0060290 transdifferentiation biological_process
GO:0061045 negative regulation of wound healing biological_process
GO:0070306 lens fiber cell differentiation biological_process
GO:0090263 positive regulation of canonical Wnt receptor signaling pathway biological_process
GO:0005622 intracellular cellular_component
GO:0005634 nucleus cellular_component
GO:0005637 nuclear inner membrane cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005667 transcription factor complex cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0005886 plasma membrane cellular_component
GO:0043235 receptor complex cellular_component
GO:0071141 SMAD protein complex cellular_component
GO:0000987 core promoter proximal region sequence-specific DNA binding molecular_function
GO:0000988 protein binding transcription factor activity molecular_function
GO:0001102 RNA polymerase II activating transcription factor binding molecular_function
GO:0003690 double-stranded DNA binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0005160 transforming growth factor beta receptor binding molecular_function
GO:0005515 protein binding molecular_function
GO:0005518 collagen binding molecular_function
GO:0008013 beta-catenin binding molecular_function
GO:0008134 transcription factor binding molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0019901 protein kinase binding molecular_function
GO:0019902 phosphatase binding molecular_function
GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity molecular_function
GO:0031490 chromatin DNA binding molecular_function
GO:0031625 ubiquitin protein ligase binding molecular_function
GO:0042803 protein homodimerization activity molecular_function
GO:0043130 ubiquitin binding molecular_function
GO:0043565 sequence-specific DNA binding molecular_function
GO:0044212 transcription regulatory region DNA binding molecular_function
GO:0046332 SMAD binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0070410 co-SMAD binding molecular_function
GO:0070412 R-SMAD binding molecular_function