lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
Symbol
LSS
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2009]
Orthologs
| Symbol | Species | |
|---|---|---|
| lss | Danio rerio | |
| Lss | Mus musculus | |
| Lss | Rattus norvegicus | |
| ERG7 | Saccharomyces cerevisiae | |
| erg7 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006694 | steroid biosynthetic process | biological_process | |
| GO:0006695 | cholesterol biosynthetic process | biological_process | |
| GO:0008202 | steroid metabolic process | biological_process | |
| GO:0016125 | sterol metabolic process | biological_process | |
| GO:0044281 | small molecule metabolic process | biological_process | |
| GO:0005783 | endoplasmic reticulum | cellular_component | |
| GO:0005789 | endoplasmic reticulum membrane | cellular_component | |
| GO:0005792 | microsome | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0000250 | lanosterol synthase activity | molecular_function | |
| GO:0003824 | catalytic activity | molecular_function | |
| GO:0016866 | intramolecular transferase activity | molecular_function | |