LIM homeobox transcription factor 1, alpha
Symbol
LMX1A
(may also be known as: None)
Organism
Human
Description
This gene encodes a homeodomain and LIM-domain containing protein. The encoded protein is a transcription factor that acts as a positive regulator of insulin gene transcription. This gene also plays a role in the development of dopamine producing neurons during embryogenesis. Mutations in this gene are associated with an increased risk of developing Parkinson's disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Orthologs
| Symbol | Species | |
|---|---|---|
| lim-6 | Caenorhabditis elegans | |
| Lmx1a | Mus musculus | |
| Lmx1a | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0001558 | regulation of cell growth | biological_process | |
| GO:0007275 | multicellular organismal development | biological_process | |
| GO:0007411 | axon guidance | biological_process | |
| GO:0021542 | dentate gyrus development | biological_process | |
| GO:0021549 | cerebellum development | biological_process | |
| GO:0021953 | central nervous system neuron differentiation | biological_process | |
| GO:0045665 | negative regulation of neuron differentiation | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | molecular_function | |
| GO:0008270 | zinc ion binding | molecular_function | |
| GO:0043565 | sequence-specific DNA binding | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |