leptin receptor
Symbol
Organism
Description
The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010]
Links to external resources
Changes associated with this gene
Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
---|---|---|---|---|---|---|---|
DAA2808 | Gene expression of LEPR increases with age | Molecular | adipose tissue | Human | LEPR | — |
GO Terms
GO ID | GO Term | GO Category | |
---|---|---|---|
GO:0006112 | energy reserve metabolic process | biological_process | |
GO:0007166 | cell surface receptor linked signaling pathway | biological_process | |
GO:0007275 | multicellular organismal development | biological_process | |
GO:0008203 | cholesterol metabolic process | biological_process | |
GO:0051346 | negative regulation of hydrolase activity | biological_process | |
GO:0005576 | extracellular region | cellular_component | |
GO:0005886 | plasma membrane | cellular_component | |
GO:0016021 | integral to membrane | cellular_component | |
GO:0004872 | receptor activity | molecular_function | |
GO:0004888 | transmembrane signaling receptor activity | molecular_function | |
GO:0004896 | cytokine receptor activity | molecular_function | |
GO:0005515 | protein binding | molecular_function | |