jun D proto-oncogene
Symbol
JUND
(may also be known as: None)
Organism
Human
Description
The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013]
Orthologs
| Symbol | Species | |
|---|---|---|
| jund | Danio rerio | |
| Jund | Mus musculus | |
| Jund | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0002076 | osteoblast development | biological_process | |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | biological_process | |
| GO:0045669 | positive regulation of osteoblast differentiation | biological_process | |
| GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | biological_process | |
| GO:0071277 | cellular response to calcium ion | biological_process | |
| GO:0000785 | chromatin | cellular_component | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0043565 | sequence-specific DNA binding | molecular_function | |
| GO:0044212 | transcription regulatory region DNA binding | molecular_function | |
| GO:0046983 | protein dimerization activity | molecular_function | |