ISL LIM homeobox 1

Symbol

ISL1 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
lim-7 Caenorhabditis elegans
isl1 Danio rerio
Isl1 Mus musculus
Isl1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3210 Gene expression of ISL1 increases with age Molecular skin Human ISL1 —

GO Terms

GO IDGO TermGO Category
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0001755 neural crest cell migration biological_process
GO:0003007 heart morphogenesis biological_process
GO:0003139 secondary heart field specification biological_process
GO:0003148 outflow tract septum morphogenesis biological_process
GO:0003151 outflow tract morphogenesis biological_process
GO:0003203 endocardial cushion morphogenesis biological_process
GO:0003215 cardiac right ventricle morphogenesis biological_process
GO:0003266 regulation of secondary heart field cardioblast proliferation biological_process
GO:0007275 multicellular organismal development biological_process
GO:0008284 positive regulation of cell proliferation biological_process
GO:0021520 spinal cord motor neuron cell fate specification biological_process
GO:0021522 spinal cord motor neuron differentiation biological_process
GO:0021524 visceral motor neuron differentiation biological_process
GO:0021559 trigeminal nerve development biological_process
GO:0021983 pituitary gland development biological_process
GO:0031016 pancreas development biological_process
GO:0031103 axon regeneration biological_process
GO:0031290 retinal ganglion cell axon guidance biological_process
GO:0032024 positive regulation of insulin secretion biological_process
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway biological_process
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein biological_process
GO:0043388 positive regulation of DNA binding biological_process
GO:0043524 negative regulation of neuron apoptosis biological_process
GO:0045665 negative regulation of neuron differentiation biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0048665 neuron fate specification biological_process
GO:0048762 mesenchymal cell differentiation biological_process
GO:0048880 sensory system development biological_process
GO:0048936 peripheral nervous system neuron axonogenesis biological_process
GO:0055010 ventricular cardiac muscle tissue morphogenesis biological_process
GO:0060037 pharyngeal system development biological_process
GO:0060379 cardiac muscle cell myoblast differentiation biological_process
GO:0060384 innervation biological_process
GO:0060413 atrial septum morphogenesis biological_process
GO:0060913 cardiac cell fate determination biological_process
GO:0071385 cellular response to glucocorticoid stimulus biological_process
GO:0090074 negative regulation of protein homodimerization activity biological_process
GO:0090090 negative regulation of canonical Wnt receptor signaling pathway biological_process
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0044424 intracellular part cellular_component
GO:0001102 RNA polymerase II activating transcription factor binding molecular_function
GO:0001105 RNA polymerase II transcription coactivator activity molecular_function
GO:0001158 enhancer sequence-specific DNA binding molecular_function
GO:0003682 chromatin binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0016922 ligand-dependent nuclear receptor binding molecular_function
GO:0030331 estrogen receptor binding molecular_function
GO:0043425 bHLH transcription factor binding molecular_function
GO:0043565 sequence-specific DNA binding molecular_function
GO:0046872 metal ion binding molecular_function