insulin receptor substrate 1

Symbol

IRS1 (may also be known as: None)

Organism

Human

Description

This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]

Orthologs

SymbolSpecies
irs1 Danio rerio
Irs1 Mus musculus
Irs1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3208 Gene expression of IRS1 decreases with age Molecular skin Human IRS1 —
DAA2807 Gene expression of IRS1 decreases with age Molecular adipose tissue Human IRS1 —

Changes associated with the orthologs of this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1709 insulin receptor substrate 1 Molecular lung Mouse Irs1 7.0% Decrease Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0002053 positive regulation of mesenchymal cell proliferation biological_process
GO:0007165 signal transduction biological_process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway biological_process
GO:0008284 positive regulation of cell proliferation biological_process
GO:0008286 insulin receptor signaling pathway biological_process
GO:0010468 regulation of gene expression biological_process
GO:0010907 positive regulation of glucose metabolic process biological_process
GO:0014065 phosphatidylinositol 3-kinase cascade biological_process
GO:0016042 lipid catabolic process biological_process
GO:0030335 positive regulation of cell migration biological_process
GO:0030879 mammary gland development biological_process
GO:0032000 positive regulation of fatty acid beta-oxidation biological_process
GO:0032868 response to insulin stimulus biological_process
GO:0032869 cellular response to insulin stimulus biological_process
GO:0034504 protein localization to nucleus biological_process
GO:0042327 positive regulation of phosphorylation biological_process
GO:0042593 glucose homeostasis biological_process
GO:0043434 response to peptide hormone stimulus biological_process
GO:0043491 protein kinase B signaling cascade biological_process
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity biological_process
GO:0045725 positive regulation of glycogen biosynthetic process biological_process
GO:0046326 positive regulation of glucose import biological_process
GO:0046627 negative regulation of insulin receptor signaling pathway biological_process
GO:0046628 positive regulation of insulin receptor signaling pathway biological_process
GO:0046676 negative regulation of insulin secretion biological_process
GO:0048009 insulin-like growth factor receptor signaling pathway biological_process
GO:0048011 nerve growth factor receptor signaling pathway biological_process
GO:0048015 phosphatidylinositol-mediated signaling biological_process
GO:0051291 protein heterooligomerization biological_process
GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway biological_process
GO:0070094 positive regulation of glucagon secretion biological_process
GO:0090275 negative regulation of somatostatin secretion biological_process
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005792 microsome cellular_component
GO:0005829 cytosol cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005899 insulin receptor complex cellular_component
GO:0005901 caveola cellular_component
GO:0004871 signal transducer activity molecular_function
GO:0005010 insulin-like growth factor-activated receptor activity molecular_function
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity molecular_function
GO:0005080 protein kinase C binding molecular_function
GO:0005158 insulin receptor binding molecular_function
GO:0005159 insulin-like growth factor receptor binding molecular_function
GO:0005515 protein binding molecular_function
GO:0042169 SH2 domain binding molecular_function
GO:0043548 phosphatidylinositol 3-kinase binding molecular_function
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity molecular_function