inositol(myo)-1(or 4)-monophosphatase 2
Symbol
IMPA2
(may also be known as: None)
Organism
Human
Description
This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder. [provided by RefSeq, Jan 2011]
Orthologs
| Symbol | Species | |
|---|---|---|
| ttx-7 | Caenorhabditis elegans | |
| CG9391 | Drosophila melanogaster | |
| zgc:110201 | Danio rerio | |
| Impa2 | Mus musculus | |
| Impa2 | Rattus norvegicus | |
| INM1 | Saccharomyces cerevisiae | |
| tol1 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2806 | Gene expression of IMPA2 increases with age | Molecular | adipose tissue | Human | IMPA2 | — |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006796 | phosphate-containing compound metabolic process | biological_process | |
| GO:0007165 | signal transduction | biological_process | |
| GO:0046854 | phosphatidylinositol phosphorylation | biological_process | |
| GO:0046855 | inositol phosphate dephosphorylation | biological_process | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0008934 | inositol monophosphate 1-phosphatase activity | molecular_function | |
| GO:0016787 | hydrolase activity | molecular_function | |
| GO:0042803 | protein homodimerization activity | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |
| GO:0052832 | inositol monophosphate 3-phosphatase activity | molecular_function | |
| GO:0052833 | inositol monophosphate 4-phosphatase activity | molecular_function | |