interleukin 2

Symbol

IL2

Organism

Human

Description

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
Il2 Mus musculus
Il2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA962 Interleukin-2 production in response to influenza vaccine declines Physiological T cell Human IL2 —

GO Terms

GO IDGO TermGO Category
GO:0001933 negative regulation of protein phosphorylation biological_process
GO:0001934 positive regulation of protein phosphorylation biological_process
GO:0002903 negative regulation of B cell apoptosis biological_process
GO:0006916 anti-apoptosis biological_process
GO:0006955 immune response biological_process
GO:0007155 cell adhesion biological_process
GO:0007204 elevation of cytosolic calcium ion concentration biological_process
GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway biological_process
GO:0007267 cell-cell signaling biological_process
GO:0008284 positive regulation of cell proliferation biological_process
GO:0030101 natural killer cell activation biological_process
GO:0030217 T cell differentiation biological_process
GO:0030307 positive regulation of cell growth biological_process
GO:0030890 positive regulation of B cell proliferation biological_process
GO:0032740 positive regulation of interleukin-17 production biological_process
GO:0034105 positive regulation of tissue remodeling biological_process
GO:0042104 positive regulation of activated T cell proliferation biological_process
GO:0042327 positive regulation of phosphorylation biological_process
GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein biological_process
GO:0045591 positive regulation of regulatory T cell differentiation biological_process
GO:0045822 negative regulation of heart contraction biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0046013 regulation of T cell homeostatic proliferation biological_process
GO:0048304 positive regulation of isotype switching to IgG isotypes biological_process
GO:0050672 negative regulation of lymphocyte proliferation biological_process
GO:0050728 negative regulation of inflammatory response biological_process
GO:0050729 positive regulation of inflammatory response biological_process
GO:0051024 positive regulation of immunoglobulin secretion biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0005125 cytokine activity molecular_function
GO:0005134 interleukin-2 receptor binding molecular_function
GO:0008083 growth factor activity molecular_function
GO:0019209 kinase activator activity molecular_function
GO:0030246 carbohydrate binding molecular_function
GO:0031851 kappa-type opioid receptor binding molecular_function
GO:0043208 glycosphingolipid binding molecular_function