inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

Symbol

IKBKB (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]

Orthologs

SymbolSpecies
ikbkb Danio rerio
Ikbkb Mus musculus
Ikbkb Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3202 Gene expression of IKBKB increases with age Molecular skin Human IKBKB —

GO Terms

GO IDGO TermGO Category
GO:0001782 B cell homeostasis biological_process
GO:0002224 toll-like receptor signaling pathway biological_process
GO:0002755 MyD88-dependent toll-like receptor signaling pathway biological_process
GO:0002756 MyD88-independent toll-like receptor signaling pathway biological_process
GO:0003009 skeletal muscle contraction biological_process
GO:0006468 protein phosphorylation biological_process
GO:0006916 anti-apoptosis biological_process
GO:0006954 inflammatory response biological_process
GO:0007249 I-kappaB kinase/NF-kappaB cascade biological_process
GO:0007252 I-kappaB phosphorylation biological_process
GO:0008063 Toll signaling pathway biological_process
GO:0009615 response to virus biological_process
GO:0009636 response to toxin biological_process
GO:0034130 toll-like receptor 1 signaling pathway biological_process
GO:0034134 toll-like receptor 2 signaling pathway biological_process
GO:0034138 toll-like receptor 3 signaling pathway biological_process
GO:0034142 toll-like receptor 4 signaling pathway biological_process
GO:0035666 TRIF-dependent toll-like receptor signaling pathway biological_process
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway biological_process
GO:0042493 response to drug biological_process
GO:0043122 regulation of I-kappaB kinase/NF-kappaB cascade biological_process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade biological_process
GO:0045087 innate immune response biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0048011 nerve growth factor receptor signaling pathway biological_process
GO:0050852 T cell receptor signaling pathway biological_process
GO:0051092 positive regulation of NF-kappaB transcription factor activity biological_process
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway biological_process
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005792 microsome cellular_component
GO:0005829 cytosol cellular_component
GO:0008385 IkappaB kinase complex cellular_component
GO:0009898 internal side of plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0035631 CD40 receptor complex cellular_component
GO:0045121 membrane raft cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0004674 protein serine/threonine kinase activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0008384 IkappaB kinase activity molecular_function
GO:0016301 kinase activity molecular_function
GO:0046982 protein heterodimerization activity molecular_function