interferon regulatory factor 8
Symbol
IRF8
(may also be known as: None)
Organism
Human
Description
Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| irf8 | Danio rerio | |
| Irf8 | Mus musculus | |
| Irf8 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | biological_process | |
| GO:0006909 | phagocytosis | biological_process | |
| GO:0006955 | immune response | biological_process | |
| GO:0019221 | cytokine-mediated signaling pathway | biological_process | |
| GO:0030099 | myeloid cell differentiation | biological_process | |
| GO:0032729 | positive regulation of interferon-gamma production | biological_process | |
| GO:0032735 | positive regulation of interleukin-12 production | biological_process | |
| GO:0042742 | defense response to bacterium | biological_process | |
| GO:0042832 | defense response to protozoan | biological_process | |
| GO:0044130 | negative regulation of growth of symbiont in host | biological_process | |
| GO:0045893 | positive regulation of transcription, DNA-dependent | biological_process | |
| GO:0060333 | interferon-gamma-mediated signaling pathway | biological_process | |
| GO:0060337 | type I interferon-mediated signaling pathway | biological_process | |
| GO:0071222 | cellular response to lipopolysaccharide | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0000975 | regulatory region DNA binding | molecular_function | |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | molecular_function | |
| GO:0003705 | sequence-specific distal enhancer binding RNA polymerase II transcription factor activity | molecular_function | |