major histocompatibility complex, class I, G

Symbol

HLA-G (may also be known as: None)

Organism

Human

Description

HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2332 HLA-G histocompatibility antigen, class I, G increases with age Molecular hippocampus Human HLA-G 30.6% Increase Gene Expression Level
DAA2333 HLA-G histocompatibility antigen, class I, G increases with age Molecular hippocampus Human HLA-G 30.5% Increase Gene Expression Level
DAA2334 HLA-G histocompatibility antigen, class I, G increases with age Molecular hippocampus Human HLA-G 26.0% Increase Gene Expression Level
DAA2347 HLA-G histocompatibility antigen, class I, G increases with age Molecular frontal lobe Human HLA-G 28.4% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I biological_process
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent biological_process
GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent biological_process
GO:0002666 positive regulation of T cell tolerance induction biological_process
GO:0002767 immune response-inhibiting cell surface receptor signaling pathway biological_process
GO:0006968 cellular defense response biological_process
GO:0019221 cytokine-mediated signaling pathway biological_process
GO:0019882 antigen processing and presentation biological_process
GO:0032735 positive regulation of interleukin-12 production biological_process
GO:0042130 negative regulation of T cell proliferation biological_process
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I biological_process
GO:0045591 positive regulation of regulatory T cell differentiation biological_process
GO:0050776 regulation of immune response biological_process
GO:0060333 interferon-gamma-mediated signaling pathway biological_process
GO:0060337 type I interferon-mediated signaling pathway biological_process
GO:2001199 negative regulation of dendritic cell differentiation biological_process
GO:0000139 Golgi membrane cellular_component
GO:0005886 plasma membrane cellular_component
GO:0012507 ER to Golgi transport vesicle membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0030670 phagocytic vesicle membrane cellular_component
GO:0031901 early endosome membrane cellular_component
GO:0042612 MHC class I protein complex cellular_component
GO:0071556 integral to lumenal side of endoplasmic reticulum membrane cellular_component
GO:0005102 receptor binding molecular_function
GO:0032393 MHC class I receptor activity molecular_function
GO:0042803 protein homodimerization activity molecular_function