major histocompatibility complex, class II, DR beta 1

Symbol

HLA-DRB1 (may also be known as: None)

Organism

Human

Description

HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008]

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2135 major histocompatibility complex, class II, DR beta 1 increases with age Molecular hippocampus Human HLA-DRB1 193.5% Increase Gene Expression Level
DAA2137 major histocompatibility complex, class II, DR beta 1 increases with age Molecular frontal lobe Human HLA-DRB1 83.0% Increase Gene Expression Level
DAA2136 major histocompatibility complex, class II, DR beta 1 increases with age Molecular parietal lobe Human HLA-DRB1 90.3% Increase Gene Expression Level
DAA2360 major histocompatibility complex, class II, DR beta 1 increases with age Molecular hippocampus Human HLA-DRB1 204.2% Increase Gene Expression Level
DAA2365 major histocompatibility complex, class II, DR beta 1 increases with age Molecular parietal lobe Human HLA-DRB1 111.1% Increase Gene Expression Level
DAA2370 major histocompatibility complex, class II, DR beta 1 increases with age Molecular frontal lobe Human HLA-DRB1 84.8% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II biological_process
GO:0006955 immune response biological_process
GO:0007165 signal transduction biological_process
GO:0019221 cytokine-mediated signaling pathway biological_process
GO:0031295 T cell costimulation biological_process
GO:0032673 regulation of interleukin-4 production biological_process
GO:0050852 T cell receptor signaling pathway biological_process
GO:0051262 protein tetramerization biological_process
GO:0060333 interferon-gamma-mediated signaling pathway biological_process
GO:2001179 regulation of interleukin-10 secretion biological_process
GO:0005765 lysosomal membrane cellular_component
GO:0005768 endosome cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0009897 external side of plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0031902 late endosome membrane cellular_component
GO:0042613 MHC class II protein complex cellular_component
GO:0032395 MHC class II receptor activity molecular_function
GO:0042605 peptide antigen binding molecular_function