major histocompatibility complex, class II, DP beta 1

Symbol

HLA-DPB1 (may also be known as: None)

Organism

Human

Description

HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
uncharacterized_M0RD Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2355 major histocompatibility complex, class II, DP beta 1 increases with age Molecular hippocampus Human HLA-DPB1 160.5% Increase Gene Expression Level
DAA2356 major histocompatibility complex, class II, DP beta 1 increases with age Molecular hippocampus Human HLA-DPB1 13.2% Increase Gene Expression Level
DAA2363 major histocompatibility complex, class II, DP beta 1 increases with age Molecular parietal lobe Human HLA-DPB1 81.5% Increase Gene Expression Level
DAA2368 major histocompatibility complex, class II, DP beta 1 increases with age Molecular frontal lobe Human HLA-DPB1 76.9% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II biological_process
GO:0006955 immune response biological_process
GO:0019221 cytokine-mediated signaling pathway biological_process
GO:0031295 T cell costimulation biological_process
GO:0050852 T cell receptor signaling pathway biological_process
GO:0060333 interferon-gamma-mediated signaling pathway biological_process
GO:0005765 lysosomal membrane cellular_component
GO:0005768 endosome cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0005886 plasma membrane cellular_component
GO:0010008 endosome membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0042613 MHC class II protein complex cellular_component