major histocompatibility complex, class II, DM alpha

Symbol

HLA-DMA (may also be known as: None)

Organism

Human

Description

HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. [provided by RefSeq, Jul 2008]

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2310 major histocompatibility complex, class II, DM alpha increases with age Molecular temporal lobe Human HLA-DMA 110.6% Increase Gene Expression Level
DAA2312 major histocompatibility complex, class II, DM alpha increases with age Molecular hippocampus Human HLA-DMA 221.5% Increase Gene Expression Level
DAA2318 major histocompatibility complex, class II, DM alpha increases with age Molecular parietal lobe Human HLA-DMA 169.9% Increase Gene Expression Level
DAA2324 major histocompatibility complex, class II, DM alpha increases with age Molecular frontal lobe Human HLA-DMA 115.5% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II biological_process
GO:0006461 protein complex assembly biological_process
GO:0006955 immune response biological_process
GO:0015031 protein transport biological_process
GO:0016064 immunoglobulin mediated immune response biological_process
GO:0019221 cytokine-mediated signaling pathway biological_process
GO:0019882 antigen processing and presentation biological_process
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II biological_process
GO:0031295 T cell costimulation biological_process
GO:0045059 positive thymic T cell selection biological_process
GO:0045582 positive regulation of T cell differentiation biological_process
GO:0050778 positive regulation of immune response biological_process
GO:0050852 T cell receptor signaling pathway biological_process
GO:0051085 chaperone mediated protein folding requiring cofactor biological_process
GO:0060333 interferon-gamma-mediated signaling pathway biological_process
GO:0005622 intracellular cellular_component
GO:0005765 lysosomal membrane cellular_component
GO:0005771 multivesicular body cellular_component
GO:0005886 plasma membrane cellular_component
GO:0010008 endosome membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0031902 late endosome membrane cellular_component
GO:0042613 MHC class II protein complex cellular_component