acetyl-CoA carboxylase alpha


ACACA (may also be known as: None)




Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]


acaca Danio rerio
Acaca Mus musculus
Acaca Rattus norvegicus
HFA1 Saccharomyces cerevisiae

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0001894 tissue homeostasis biological_process
GO:0006084 acetyl-CoA metabolic process biological_process
GO:0006112 energy reserve metabolic process biological_process
GO:0006629 lipid metabolic process biological_process
GO:0006633 fatty acid biosynthetic process biological_process
GO:0014070 response to organic cyclic compound biological_process
GO:0019432 triglyceride biosynthetic process biological_process
GO:0031325 positive regulation of cellular metabolic process biological_process
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process biological_process
GO:0042493 response to drug biological_process
GO:0044255 cellular lipid metabolic process biological_process
GO:0044268 multicellular organismal protein metabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0051289 protein homotetramerization biological_process
GO:0055088 lipid homeostasis biological_process
GO:0005625 soluble fraction cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005739 mitochondrion cellular_component
GO:0005829 cytosol cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0003989 acetyl-CoA carboxylase activity molecular_function
GO:0004075 biotin carboxylase activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0009374 biotin binding molecular_function
GO:0016874 ligase activity molecular_function
GO:0046872 metal ion binding molecular_function