acetyl-CoA carboxylase alpha

Symbol

ACACA (may also be known as: None)

Organism

Human

Description

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
Acaca Rattus norvegicus
ACC Drosophila melanogaster
Acaca Mus musculus
T28F3.5 Caenorhabditis elegans
acaca Danio rerio
ACC1 Saccharomyces cerevisiae

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0001894 tissue homeostasis biological_process
GO:0006084 acetyl-CoA metabolic process biological_process
GO:0006112 energy reserve metabolic process biological_process
GO:0006629 lipid metabolic process biological_process
GO:0006633 fatty acid biosynthetic process biological_process
GO:0014070 response to organic cyclic compound biological_process
GO:0019432 triglyceride biosynthetic process biological_process
GO:0031325 positive regulation of cellular metabolic process biological_process
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process biological_process
GO:0042493 response to drug biological_process
GO:0044255 cellular lipid metabolic process biological_process
GO:0044268 multicellular organismal protein metabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0051289 protein homotetramerization biological_process
GO:0055088 lipid homeostasis biological_process
GO:0005625 soluble fraction cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005739 mitochondrion cellular_component
GO:0005829 cytosol cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0003989 acetyl-CoA carboxylase activity molecular_function
GO:0004075 biotin carboxylase activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0009374 biotin binding molecular_function
GO:0016874 ligase activity molecular_function
GO:0046872 metal ion binding molecular_function