hydroxyacyl-CoA dehydrogenase

Symbol

HADH (may also be known as: None)

Organism

Human

Description

This gene is a member of the 3-hydroxyacyl-CoA dehydrogenase gene family. The encoded protein functions in the mitochondrial matrix to catalyze the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. Its enzymatic activity is highest with medium-chain-length fatty acids. Mutations in this gene cause one form of familial hyperinsulinemic hypoglycemia. The human genome contains a related pseudogene of this gene on chromosome 15. [provided by RefSeq, May 2010]

Orthologs

SymbolSpecies
F54C8.1 Caenorhabditis elegans
hadh Danio rerio
Hadh Mus musculus
Hadh Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3173 Gene expression of HADH decreases with age Molecular skin Human HADH —

GO Terms

GO IDGO TermGO Category
GO:0006631 fatty acid metabolic process biological_process
GO:0006635 fatty acid beta-oxidation biological_process
GO:0009725 response to hormone stimulus biological_process
GO:0014823 response to activity biological_process
GO:0032868 response to insulin stimulus biological_process
GO:0042493 response to drug biological_process
GO:0044255 cellular lipid metabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0046676 negative regulation of insulin secretion biological_process
GO:0005634 nucleus cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005739 mitochondrion cellular_component
GO:0005743 mitochondrial inner membrane cellular_component
GO:0005759 mitochondrial matrix cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0050662 coenzyme binding molecular_function
GO:0070403 NAD+ binding molecular_function