parvin, beta
Symbol
PARVB
(may also be known as: None)
Organism
Human
Description
This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Orthologs
| Symbol | Species | |
|---|---|---|
| parvb | Danio rerio | |
| Parvb | Mus musculus | |
| Parvb | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0007155 | cell adhesion | biological_process | |
| GO:0034329 | cell junction assembly | biological_process | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0005856 | cytoskeleton | cellular_component | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0005925 | focal adhesion | cellular_component | |
| GO:0030054 | cell junction | cellular_component | |
| GO:0003779 | actin binding | molecular_function | |