homeodomain interacting protein kinase 2

Symbol

HIPK2 (may also be known as: None)

Organism

Human

Description

This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Orthologs

SymbolSpecies
hipk2 Danio rerio
Hipk2 Mus musculus
Hipk2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2675 Hypermethylation of HIPK2 is positively correlated with age Molecular blood Human HIPK2 —

GO Terms

GO IDGO TermGO Category
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0001654 eye development biological_process
GO:0006468 protein phosphorylation biological_process
GO:0006915 apoptotic process biological_process
GO:0006974 response to DNA damage stimulus biological_process
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator biological_process
GO:0007179 transforming growth factor beta receptor signaling pathway biological_process
GO:0007224 smoothened signaling pathway biological_process
GO:0007628 adult walking behavior biological_process
GO:0008284 positive regulation of cell proliferation biological_process
GO:0008629 induction of apoptosis by intracellular signals biological_process
GO:0009952 anterior/posterior pattern specification biological_process
GO:0010842 retina layer formation biological_process
GO:0018105 peptidyl-serine phosphorylation biological_process
GO:0018107 peptidyl-threonine phosphorylation biological_process
GO:0019048 virus-host interaction biological_process
GO:0030182 neuron differentiation biological_process
GO:0030218 erythrocyte differentiation biological_process
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway biological_process
GO:0030514 negative regulation of BMP signaling pathway biological_process
GO:0030578 PML body organization biological_process
GO:0032092 positive regulation of protein binding biological_process
GO:0042771 DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis biological_process
GO:0043388 positive regulation of DNA binding biological_process
GO:0043524 negative regulation of neuron apoptosis biological_process
GO:0045766 positive regulation of angiogenesis biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0046330 positive regulation of JNK cascade biological_process
GO:0048596 embryonic camera-type eye morphogenesis biological_process
GO:0050882 voluntary musculoskeletal movement biological_process
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity biological_process
GO:0051726 regulation of cell cycle biological_process
GO:0060059 embryonic retina morphogenesis in camera-type eye biological_process
GO:0060235 lens induction in camera-type eye biological_process
GO:0060395 SMAD protein signal transduction biological_process
GO:0061072 iris morphogenesis biological_process
GO:0071456 cellular response to hypoxia biological_process
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005813 centrosome cellular_component
GO:0016604 nuclear body cellular_component
GO:0016605 PML body cellular_component
GO:0031965 nuclear membrane cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0001102 RNA polymerase II activating transcription factor binding molecular_function
GO:0001105 RNA polymerase II transcription coactivator activity molecular_function
GO:0003714 transcription corepressor activity molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0004674 protein serine/threonine kinase activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0016772 transferase activity, transferring phosphorus-containing groups molecular_function
GO:0046332 SMAD binding molecular_function
GO:0046790 virion binding molecular_function