homeodomain interacting protein kinase 2

Symbol

HIPK2 (may also be known as: None)

Organism

Human

Description

This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Orthologs

Symbol	Species
hipk2	Danio rerio
Hipk2	Mus musculus
Hipk2	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA2675	Hypermethylation of HIPK2 is positively correlated with age	Molecular	blood	Human	HIPK2	—

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GO Terms

GO ID	GO Term	GO Category
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological_process
GO:0001654	eye development	biological_process
GO:0006468	protein phosphorylation	biological_process
GO:0006915	apoptotic process	biological_process
GO:0006974	response to DNA damage stimulus	biological_process
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	biological_process
GO:0007179	transforming growth factor beta receptor signaling pathway	biological_process
GO:0007224	smoothened signaling pathway	biological_process
GO:0007628	adult walking behavior	biological_process
GO:0008284	positive regulation of cell proliferation	biological_process
GO:0008629	induction of apoptosis by intracellular signals	biological_process
GO:0009952	anterior/posterior pattern specification	biological_process
GO:0010842	retina layer formation	biological_process
GO:0018105	peptidyl-serine phosphorylation	biological_process
GO:0018107	peptidyl-threonine phosphorylation	biological_process
GO:0019048	virus-host interaction	biological_process
GO:0030182	neuron differentiation	biological_process
GO:0030218	erythrocyte differentiation	biological_process
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	biological_process
GO:0030514	negative regulation of BMP signaling pathway	biological_process
GO:0030578	PML body organization	biological_process
GO:0032092	positive regulation of protein binding	biological_process
GO:0042771	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	biological_process
GO:0043388	positive regulation of DNA binding	biological_process
GO:0043524	negative regulation of neuron apoptosis	biological_process
GO:0045766	positive regulation of angiogenesis	biological_process
GO:0045893	positive regulation of transcription, DNA-dependent	biological_process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological_process
GO:0046330	positive regulation of JNK cascade	biological_process
GO:0048596	embryonic camera-type eye morphogenesis	biological_process
GO:0050882	voluntary musculoskeletal movement	biological_process
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	biological_process
GO:0051726	regulation of cell cycle	biological_process
GO:0060059	embryonic retina morphogenesis in camera-type eye	biological_process
GO:0060235	lens induction in camera-type eye	biological_process
GO:0060395	SMAD protein signal transduction	biological_process
GO:0061072	iris morphogenesis	biological_process
GO:0071456	cellular response to hypoxia	biological_process
GO:0005634	nucleus	cellular_component
GO:0005737	cytoplasm	cellular_component
GO:0005813	centrosome	cellular_component
GO:0016604	nuclear body	cellular_component
GO:0016605	PML body	cellular_component
GO:0031965	nuclear membrane	cellular_component
GO:0000166	nucleotide binding	molecular_function
GO:0001102	RNA polymerase II activating transcription factor binding	molecular_function
GO:0001105	RNA polymerase II transcription coactivator activity	molecular_function
GO:0003714	transcription corepressor activity	molecular_function
GO:0004672	protein kinase activity	molecular_function
GO:0004674	protein serine/threonine kinase activity	molecular_function
GO:0005515	protein binding	molecular_function
GO:0005524	ATP binding	molecular_function
GO:0016772	transferase activity, transferring phosphorus-containing groups	molecular_function
GO:0046332	SMAD binding	molecular_function
GO:0046790	virion binding	molecular_function
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