Rap guanine nucleotide exchange factor (GEF) 1

Symbol

RAPGEF1 (may also be known as: None)

Organism

Human

Description

This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
C3G Drosophila melanogaster
rapgef1b Danio rerio
Rapgef1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3161 Gene expression of RAPGEF1 increases with age Molecular skin Human RAPGEF1 —

GO Terms

GO IDGO TermGO Category
GO:0000186 activation of MAPKK activity biological_process
GO:0001568 blood vessel development biological_process
GO:0007165 signal transduction biological_process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway biological_process
GO:0016337 cell-cell adhesion biological_process
GO:0048008 platelet-derived growth factor receptor signaling pathway biological_process
GO:0048011 nerve growth factor receptor signaling pathway biological_process
GO:0050790 regulation of catalytic activity biological_process
GO:0051056 regulation of small GTPase mediated signal transduction biological_process
GO:0005622 intracellular cellular_component
GO:0005768 endosome cellular_component
GO:0005829 cytosol cellular_component
GO:0005085 guanyl-nucleotide exchange factor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0017124 SH3 domain binding molecular_function