LSM1, U6 small nuclear RNA associated

Symbol

LSM1 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011]

Orthologs

SymbolSpecies
lsm-1 Caenorhabditis elegans
LSm1 Drosophila melanogaster
lsm1 Danio rerio
Lsm1 Mus musculus
Lsm1 Rattus norvegicus
LSM1 Saccharomyces cerevisiae
lsm1 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2886 Gene expression of LSM1 increases with age Molecular adipose tissue Human LSM1 —

GO Terms

GO IDGO TermGO Category
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay biological_process
GO:0000375 RNA splicing, via transesterification reactions biological_process
GO:0006397 mRNA processing biological_process
GO:0008380 RNA splicing biological_process
GO:0010467 gene expression biological_process
GO:0016070 RNA metabolic process biological_process
GO:0016071 mRNA metabolic process biological_process
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay biological_process
GO:0071044 histone mRNA catabolic process biological_process
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0030529 ribonucleoprotein complex cellular_component
GO:0003723 RNA binding molecular_function
GO:0005515 protein binding molecular_function