ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
Symbol
ST6GALNAC4
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein prefers glycoproteins rather than glycolipids as substrates and shows restricted substrate specificity, utilizing only the trisaccharide sequence Neu5Ac-alpha-2,3-Gal-beta-1,3-GalNAc. In addition, it is involved in the synthesis of ganglioside GD1A from GM1B. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| St6galnac4 | Mus musculus | |
| siat7D | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA3794 | Gene expression of ST6GALNAC4 decreases with age | Molecular | skin | Human | ST6GALNAC4 | — |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006486 | protein glycosylation | biological_process | |
| GO:0006664 | glycolipid metabolic process | biological_process | |
| GO:0016266 | O-glycan processing | biological_process | |
| GO:0043687 | post-translational protein modification | biological_process | |
| GO:0044267 | cellular protein metabolic process | biological_process | |
| GO:0000139 | Golgi membrane | cellular_component | |
| GO:0005625 | soluble fraction | cellular_component | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005794 | Golgi apparatus | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0030173 | integral to Golgi membrane | cellular_component | |
| GO:0008373 | sialyltransferase activity | molecular_function | |
| GO:0047290 | (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity | molecular_function | |