GTP cyclohydrolase I feedback regulator
Symbol
GCHFR
(may also be known as: None)
Organism
Human
Description
GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| gfrp-1 | Caenorhabditis elegans | |
| gchfr | Danio rerio | |
| Gchfr | Mus musculus | |
| Gchfr | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2801 | Gene expression of GCHFR decreases with age | Molecular | adipose tissue | Human | GCHFR | — |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006461 | protein complex assembly | biological_process | |
| GO:0006809 | nitric oxide biosynthetic process | biological_process | |
| GO:0009890 | negative regulation of biosynthetic process | biological_process | |
| GO:0042133 | neurotransmitter metabolic process | biological_process | |
| GO:0043105 | negative regulation of GTP cyclohydrolase I activity | biological_process | |
| GO:0044281 | small molecule metabolic process | biological_process | |
| GO:0046209 | nitric oxide metabolic process | biological_process | |
| GO:0050999 | regulation of nitric-oxide synthase activity | biological_process | |
| GO:0051291 | protein heterooligomerization | biological_process | |
| GO:0005625 | soluble fraction | cellular_component | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0030425 | dendrite | cellular_component | |
| GO:0031965 | nuclear membrane | cellular_component | |
| GO:0042470 | melanosome | cellular_component | |
| GO:0043234 | protein complex | cellular_component | |
| GO:0004857 | enzyme inhibitor activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0016597 | amino acid binding | molecular_function | |
| GO:0016787 | hydrolase activity | molecular_function | |
| GO:0030742 | GTP-dependent protein binding | molecular_function | |
| GO:0043106 | GTP cyclohydrolase I binding | molecular_function | |