asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
Symbol
ASPM
(may also be known as: None)
Organism
Human
Description
This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
Orthologs
| Symbol | Species | |
|---|---|---|
| asp | Drosophila melanogaster | |
| aspm | Danio rerio | |
| Aspm | Mus musculus | |
| Aspm | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0007049 | cell cycle | biological_process | |
| GO:0007067 | mitosis | biological_process | |
| GO:0021873 | forebrain neuroblast division | biological_process | |
| GO:0045665 | negative regulation of neuron differentiation | biological_process | |
| GO:0045769 | negative regulation of asymmetric cell division | biological_process | |
| GO:0051301 | cell division | biological_process | |
| GO:0051661 | maintenance of centrosome location | biological_process | |
| GO:0000922 | spindle pole | cellular_component | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005516 | calmodulin binding | molecular_function | |