RAD54 homolog B (S. cerevisiae)
Symbol
RAD54B
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene belongs to the DEAD-like helicase superfamily. It shares similarity with Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This protein binds to double-stranded DNA, and displays ATPase activity in the presence of DNA. This gene is highly expressed in testis and spleen, which suggests active roles in meiotic and mitotic recombination. Homozygous mutations of this gene were observed in primary lymphoma and colon cancer. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| rad54b | Danio rerio | |
| Rad54b | Mus musculus | |
| Rad54b | Rattus norvegicus | |
| Fsbp | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0000724 | double-strand break repair via homologous recombination | biological_process | |
| GO:0006281 | DNA repair | biological_process | |
| GO:0006312 | mitotic recombination | biological_process | |
| GO:0006974 | response to DNA damage stimulus | biological_process | |
| GO:0007131 | reciprocal meiotic recombination | biological_process | |
| GO:0010212 | response to ionizing radiation | biological_process | |
| GO:0032508 | DNA duplex unwinding | biological_process | |
| GO:0042493 | response to drug | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0003677 | DNA binding | molecular_function | |
| GO:0003678 | DNA helicase activity | molecular_function | |
| GO:0003724 | RNA helicase activity | molecular_function | |
| GO:0004386 | helicase activity | molecular_function | |
| GO:0005524 | ATP binding | molecular_function | |
| GO:0015616 | DNA translocase activity | molecular_function | |
| GO:0016787 | hydrolase activity | molecular_function | |