glucose-6-phosphate dehydrogenase

Symbol

G6PD (may also be known as: None)

Organism

Human

Description

This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
gspd-1 Caenorhabditis elegans
Zw Drosophila melanogaster
g6pd Danio rerio
G6pdx Mus musculus
G6pdx Rattus norvegicus
ZWF1 Saccharomyces cerevisiae
zwf1 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3140 Gene expression of G6PD decreases with age Molecular skin Human G6PD —

GO Terms

GO IDGO TermGO Category
GO:0001816 cytokine production biological_process
GO:0005975 carbohydrate metabolic process biological_process
GO:0006006 glucose metabolic process biological_process
GO:0006098 pentose-phosphate shunt biological_process
GO:0006629 lipid metabolic process biological_process
GO:0006695 cholesterol biosynthetic process biological_process
GO:0006740 NADPH regeneration biological_process
GO:0006749 glutathione metabolic process biological_process
GO:0009051 pentose-phosphate shunt, oxidative branch biological_process
GO:0010734 negative regulation of protein glutathionylation biological_process
GO:0019322 pentose biosynthetic process biological_process
GO:0034599 cellular response to oxidative stress biological_process
GO:0043249 erythrocyte maturation biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0046390 ribose phosphate biosynthetic process biological_process
GO:0051156 glucose 6-phosphate metabolic process biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0005737 cytoplasm cellular_component
GO:0005813 centrosome cellular_component
GO:0005829 cytosol cellular_component
GO:0009898 internal side of plasma membrane cellular_component
GO:0043231 intracellular membrane-bounded organelle cellular_component
GO:0004345 glucose-6-phosphate dehydrogenase activity molecular_function
GO:0005536 glucose binding molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0042803 protein homodimerization activity molecular_function
GO:0050661 NADP binding molecular_function