RPTOR independent companion of MTOR, complex 2

Symbol

RICTOR (may also be known as: None)

Organism

Human

Description

RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]

Orthologs

SymbolSpecies
rict-1 Caenorhabditis elegans
rictor Drosophila melanogaster
rictorb Danio rerio
Rictor Mus musculus
Rictor Rattus norvegicus
TSC11 Saccharomyces cerevisiae
ste16 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2128 RPTOR independent companion of MTOR, complex 2 decreases with age Molecular ovary Human RICTOR 35.1% Decrease Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0007173 epidermal growth factor receptor signaling pathway biological_process
GO:0008543 fibroblast growth factor receptor signaling pathway biological_process
GO:0009790 embryo development biological_process
GO:0030838 positive regulation of actin filament polymerization biological_process
GO:0031295 T cell costimulation biological_process
GO:0031532 actin cytoskeleton reorganization biological_process
GO:0032008 positive regulation of TOR signaling cascade biological_process
GO:0032314 regulation of Rac GTPase activity biological_process
GO:0032956 regulation of actin cytoskeleton organization biological_process
GO:0048011 nerve growth factor receptor signaling pathway biological_process
GO:0048015 phosphatidylinositol-mediated signaling biological_process
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation biological_process
GO:0051896 regulation of protein kinase B signaling cascade biological_process
GO:0005829 cytosol cellular_component
GO:0031932 TORC2 complex cellular_component
GO:0005488 binding molecular_function
GO:0005515 protein binding molecular_function
GO:0043022 ribosome binding molecular_function